Performance Metrics for fast web apps. This article handles lots of quirks of JavaScript in a browser. In conclusion, it’s not obvious which metrics should be used, but once you know it, it’s not too difficult:

Measure time starting at event.timeStamp

Measure time ending at performance.now() in a requestAnimationFrame()

Ignore anything that happened while the tab was not focused

Aggregate data using “% of events that are under target”

Visualize multiple thresholds